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Protomer A of WT Mpro is colored white and protomer B of WT Mpro is colored black, nirmatrelvir in WT Mpro-nirmatrelvir intricate structure is demonstrated as environmentally friendly sticks, protomer A in the mutant composition is colored marine and protomer B with the mutant construction is coloured orange, nirmatrelvir in mutant Mpro-nirmatrelv

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